Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 13/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13012888 | 0.82 | MAT2A (0.38) | MAT2APRMT5LMNA | |
| SCHEMBL13012735 | 0.80 | HPGD (0.37) | MAT2A | |
| SCHEMBL13012886 | 0.78 | MAT2A (0.35) | MAT2APRMT5CYP1A2LMNA | |
| SCHEMBL13012732 | 0.77 | MAT2A (0.34) | MAT2APRMT5CYP1A2 | |
| SCHEMBL3434846 | 0.68 | MAT2A (0.33) | MAT2ALMNA | |
| SCHEMBL2726665 | 0.67 | ADORA3 (0.51) | — | |
| SCHEMBL3433377 | 0.60 | MAT2A (0.39) | MAT2A | |
| SCHEMBL13012896 | 0.60 | BRD4 (0.39) | MAT2ALMNA | |
| SCHEMBL22103638 | 0.59 | MAT2A (0.76) | MAT2APRMT5CYP1A2 | |
| SCHEMBL13012731 | 0.58 | BRD4 (0.38) | MAT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |