Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 11/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13012886 | 0.86 | MAT2A (0.35) | MAT2AALDH1A1USP2GFERKDM4E | |
| SCHEMBL13012894 | 0.81 | KMT2A (0.39) | MAT2AALDH1A1MAPK1GFERKDM4E | |
| SCHEMBL3432096 | 0.80 | BRD4 (0.39) | MAT2AALDH1A1MAPK1USP2KDM4E | |
| SCHEMBL2726665 | 0.78 | ADORA3 (0.51) | ALDH1A1USP2KDM4EGAA | |
| SCHEMBL13012888 | 0.73 | MAT2A (0.38) | MAT2AALDH1A1GFERKDM4EKMT2A | |
| SCHEMBL13012732 | 0.72 | MAT2A (0.34) | MAT2AALDH1A1 | |
| SCHEMBL3435001 | 0.70 | ALDH1A1 (0.41) | ALDH1A1USP2KDM4ELMNAMAPT | |
| SCHEMBL13012736 | 0.68 | MAT2A (0.36) | MAT2ALMNA | |
| SCHEMBL3434014 | 0.67 | BRD4 (0.45) | MAT2AALDH1A1MAPK1KDM4EKMT2A | |
| SCHEMBL13014431 | 0.67 | ADORA3 (0.52) | ALDH1A1USP2KDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |