Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014431 | 0.89 | ADORA3 (0.52) | ADORA3KDM4EALDH1A1ACHEABCC1 | |
| SCHEMBL13012894 | 0.88 | KMT2A (0.39) | KDM4EALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL3435001 | 0.87 | ALDH1A1 (0.41) | ADORA3KDM4EALDH1A1ACHEABCC1 | |
| SCHEMBL13014429 | 0.86 | ADORA3 (0.51) | ADORA3KDM4EALDH1A1ACHEBRD4 | |
| SCHEMBL13014248 | 0.85 | ABCC1 (0.48) | ADORA3KDM4EALDH1A1ACHEABCC1 | |
| SCHEMBL13014421 | 0.84 | ADORA3 (0.49) | ADORA3KDM4EALDH1A1ACHEKDM4A | |
| SCHEMBL13014414 | 0.84 | ADORA3 (0.49) | ADORA3KDM4EALDH1A1ACHEABCC1 | |
| SCHEMBL13014427 | 0.83 | ADORA3 (0.48) | ADORA3KDM4EALDH1A1ACHEABCC1 | |
| SCHEMBL13014412 | 0.83 | ADORA3 (0.48) | ADORA3KDM4EALDH1A1ACHEKDM4A | |
| SCHEMBL13014415 | 0.83 | ALDH1A1 (0.48) | ADORA3KDM4EALDH1A1ACHEUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445913-B1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCH (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2445913-B1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCH (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8629272-B2 | Tricyclic pyrimidine derivatives as wnt antagonists | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-06-21 | — | — | US | disclosed |
| EP-2445913-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | Deutsches Krebsforschungszentrum (DE) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010149783-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149783-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266985-A1 | Tricyclic Pyrimidine Derivatives as Wnt antagonists | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266985-A1 | Tricyclic Pyrimidine Derivatives as Wnt antagonists | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157481-A1 | TRICYCLIC PYRIMIDINE DERIVATIVES AS WNT ANTAGONISTS | WNT1, WNT3, WNT3A | ADORA3 40/4885KDM4E 3910/4885ALDH1A1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.