Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014429 | 0.95 | ADORA3 (0.51) | ADORA3ACHECACNA1DKDM4EALDH1A1 | |
| SCHEMBL3433331 | 0.93 | CASP3 (0.49) | ADORA3ACHEKDM4EALDH1A1NPEPPS | |
| SCHEMBL13013473 | 0.90 | HPGD (0.49) | ABCC1ADORA3ACHECACNA1DKDM4E | |
| SCHEMBL13014289 | 0.90 | ALDH1A1 (0.44) | ABCC1ACHECACNA1DKDM4EALDH1A1 | |
| SCHEMBL13013458 | 0.90 | ADORA3 (0.44) | ABCC1ADORA3ACHEKDM4EALDH1A1 | |
| SCHEMBL13012935 | 0.89 | ADORA3 (0.49) | ABCC1ADORA3ACHECACNA1DKDM4E | |
| SCHEMBL13013490 | 0.88 | ADORA3 (0.48) | ABCC1ADORA3ACHECACNA1DKDM4E | |
| SCHEMBL13013560 | 0.87 | ADORA3 (0.46) | ADORA3ACHEKDM4EALDH1A1MAPT | |
| SCHEMBL13014273 | 0.87 | ADORA3 (0.47) | ABCC1ADORA3ACHECACNA1DKDM4E | |
| SCHEMBL13013037 | 0.87 | ABCC1 (0.46) | ABCC1ADORA3ACHECACNA1DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |