Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031333 | 0.87 | GFER (0.40) | SMN1; SMN2NPC1RAB9AGFERALDH1A1 | |
| SCHEMBL12605880 | 0.80 | ALDH1A1 (0.45) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL11736157 | 0.79 | GFER (0.56) | SMN1; SMN2NPC1RAB9AGFERALDH1A1 | |
| Hydrochloric Acid SCHEMBL3586167 | 0.78 | GFER (0.55) | SMN1; SMN2NPC1RAB9AGFERALDH1A1 | |
| SCHEMBL13031189 | 0.75 | ALDH1A1 (0.36) | NPC1ALDH1A1KMT2ATSHRPTGS2 | |
| SCHEMBL14156258 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2GFERALDH1A1FPR2MEN1 | |
| SCHEMBL369240 | 0.70 | ALPL (0.54) | SMN1; SMN2GFERALDH1A1KMT2A | |
| SCHEMBL3594313 | 0.69 | GFER (0.56) | SMN1; SMN2NPC1RAB9AGFERALDH1A1 | |
| Hydrochloric Acid SCHEMBL28835895 | 0.68 | ALPL (0.55) | SMN1; SMN2GFERALDH1A1KMT2A | |
| SCHEMBL28938190 | 0.68 | ALPL (0.53) | SMN1; SMN2GFERALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | SMN1; SMN2 4711/4885NPC1 1365/4885RAB9A 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.