Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13621747 | 0.88 | CACNA1G (0.87) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4578208 | 0.88 | KDM4E (0.85) | CYP2D6CYP2C19L3MBTL1MAPK1DRD4 | |
| SCHEMBL15275436 | 0.84 | KMT2A (0.83) | ALDH1A1CYP2D6L3MBTL1MAPK1DRD4 | |
| SCHEMBL28632862 | 0.84 | MAPK1 (0.91) | ALDH1A1L3MBTL1MAPK1CACNA1GMEN1 | |
| SCHEMBL4753148 | 0.84 | KDM4E (0.70) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL19873508 | 0.83 | CACNA1G (0.78) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31510211 | 0.82 | KDM4E (0.76) | CYP2D6CYP2C19L3MBTL1MAPK1DRD4 | |
| SCHEMBL15275435 | 0.82 | USP2 (0.61) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3970369 | 0.82 | L3MBTL1 (0.97) | SMN1; SMN2ALDH1A1CYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL11240406 | 0.82 | L3MBTL1 (0.97) | SMN1; SMN2ALDH1A1CYP2D6CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498599-B1 | ANALGESIC THAT BINDS FILAMIN A | PAIN THERAPEUTICS INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-20100279997-A1 | ANALGESIC THAT BINDS FILAMIN A | PAIN THERAPEUTICS | 2010-11-04 | — | — | US | disclosed |
| WO-2010051374-A1 | ANALGESIC THAT BINDS FILAMIN A | PAIN THERAPEUTICS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279997-A1 | ANALGESIC THAT BINDS FILAMIN A | FLNA, FLNB, OPRL1 | SMN1; SMN2 843/4885ALDH1A1 1476/4885CYP2D6 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.