Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | UBE2N | P61088 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580492 | 0.91 | KDM4E (0.82) | KDM4ESMN1; SMN2CYP2D6MAPTPOLB | |
| SCHEMBL13621747 | 0.85 | CACNA1G (0.87) | KDM4ESMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL16371128 | 0.85 | KDM4E (0.77) | KDM4ESMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL9330581 | 0.84 | SMN1; SMN2 (0.74) | KDM4ESMN1; SMN2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL31302688 | 0.84 | SMN1; SMN2 (0.74) | KDM4ESMN1; SMN2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL24355418 | 0.84 | KDM4E (0.97) | KDM4ESMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL13033243 | 0.84 | SMN1; SMN2 (0.72) | KDM4ESMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL15275480 | 0.83 | HTR7 (0.76) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL16392457 | 0.82 | SMN1; SMN2 (0.97) | KDM4ESMN1; SMN2CYP2C19MAPTPOLB | |
| SCHEMBL4579674 | 0.82 | SMN1; SMN2 (0.97) | KDM4ESMN1; SMN2CYP2C19MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| US-8039505-B2 | Compounds for modulating T-cells | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293739-A1 | COMPOUNDS FOR MODULATING T-CELLS | CD4, HLA-DRB1, CD74 | KDM4E 1748/4885SMN1; SMN2 1217/4885ALDH1A1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.