Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.49 |
| ▸ | FABP3 | P05413 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387049 | 0.81 | CES2 (0.48) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL16318050 | 0.79 | KDM4E (0.54) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL28063083 | 0.79 | KDM4E (0.55) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL28030166 | 0.78 | KDM4E (0.47) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL2624008 | 0.76 | HPGD (0.63) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL355272 | 0.76 | TDP1 (0.61) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL31496763 | 0.76 | KDM4E (0.45) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL3984461 | 0.76 | KDM4E (0.51) | KDM4EFABP4FABP3KMT2ATRPM4 | |
| SCHEMBL7974559 | 0.75 | KDM4E (0.57) | KDM4EFABP4FABP3MEN1KMT2A | |
| SCHEMBL1903512 | 0.75 | KDM4E (0.50) | KDM4EFABP4FABP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633160-B2 | Small molecule inhibitors of PDZ interactions | NONO INC. (CA) | 2014-01-21 | — | — | US | disclosed |
| US-20100298360-A1 | SMALL MOLECULE INHIBITORS OF PDZ INTERACTIONS | BELMARES MICHAEL P | 2010-11-25 | — | — | US | disclosed |
| US-20090062213-A1 | Small Molecule Inhibitors of PDZ Interactions | ARBOR VITA CORPORATION (US) | 2009-03-05 | — | — | US | disclosed |
| US-20080227684-A1 | Small Molecule Inhibitors of PDZ Interactions | NONO INC. (CA) | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062213-A1 | Small Molecule Inhibitors of PDZ Interactions | PDLIM5, DAB2IP, PSD | KDM4E 4235/4885FABP4 1041/4885FABP3 153/4885 |
| US-20080227684-A1 | Small Molecule Inhibitors of PDZ Interactions | PDLIM5, DAB2IP, PSD | KDM4E 4235/4885FABP4 1041/4885FABP3 153/4885 |
| US-20100298360-A1 | SMALL MOLECULE INHIBITORS OF PDZ INTERACTIONS | PDLIM5, DAB2IP, PSD | KDM4E 4235/4885FABP4 1041/4885FABP3 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.