Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 3/20 | 0.49 |
| ▸ | FABP3 | P05413 | 1/20 | 0.49 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264765 | 0.84 | ALDH1A1 (0.41) | KDM4EMEN1KMT2AHPGDCYP3A4 | |
| SCHEMBL4607469 | 0.84 | KDM4E (0.49) | KDM4EFABP4FABP3TRPM4TDP1 | |
| SCHEMBL16181442 | 0.82 | FABP4 (0.50) | KDM4EFABP4TDP1L3MBTL1MEN1 | |
| SCHEMBL20999136 | 0.82 | CA12 (0.55) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8009873 | 0.81 | KDM4E (0.54) | KDM4EFABP4FABP3TRPM4L3MBTL1 | |
| SCHEMBL28030166 | 0.81 | KDM4E (0.47) | KDM4EFABP4FABP3TRPM4TDP1 | |
| SCHEMBL22904377 | 0.81 | ALDH1A1 (0.41) | KDM4EFABP4L3MBTL1MEN1KMT2A | |
| SCHEMBL13921287 | 0.81 | PLK1 (0.59) | KDM4EFABP4TDP1MEN1KMT2A | |
| SCHEMBL6497268 | 0.80 | ITGB3 (0.53) | KDM4EFABP4FABP3TRPM4MEN1 | |
| SCHEMBL16318050 | 0.79 | KDM4E (0.54) | KDM4EFABP4FABP3TRPM4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633160-B2 | Small molecule inhibitors of PDZ interactions | NONO INC. (CA) | 2014-01-21 | — | — | US | disclosed |
| US-7935825-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2011-05-03 | — | — | US | disclosed |
| EP-1436264-B9 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | ALLERGAN INC (US) | 2009-05-06 | — | — | EP | disclosed |
| US-20090062213-A1 | Small Molecule Inhibitors of PDZ Interactions | ARBOR VITA CORPORATION (US) | 2009-03-05 | — | — | US | disclosed |
| EP-1436264-B1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | ALLERGAN INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20070219255-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | BURK ROBERT M | 2007-09-20 | — | — | US | disclosed |
| US-7214678-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20060217349-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2006-09-28 | — | — | US | disclosed |
| US-7098223-B2 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050032746-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2005-02-10 | — | — | US | disclosed |
| US-6825221-B2 | PROSTAGLANDIN INHIBITORS FOR TREATING RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS, POST-OPERATIVE PAIN, PAIN ASSOCIATED WITH DENTAL | ALLERGAN, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1436264-A1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | Allergan, Inc. (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030078236-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | ALLERGAN, INC. | 2003-04-24 | — | — | US | disclosed |
| WO-2003033470-A1 | ARYLSULFANYL AND HETEROARYLSULFANYL DERIVATIVES FOR TREATING PAIN | ALLERGAN, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062213-A1 | Small Molecule Inhibitors of PDZ Interactions | PDLIM5, DAB2IP, PSD | KDM4E 4235/4885FABP4 1041/4885FABP3 153/4885 |
| US-20070219255-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | KDM4E 1642/4885FABP4 3119/4885FABP3 3711/4885 |
| US-20050032746-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | KDM4E 1642/4885FABP4 3119/4885FABP3 3711/4885 |
| US-20030078236-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRD1, OPRK1, OPRL1 | KDM4E 2236/4885FABP4 3124/4885FABP3 3518/4885 |
| US-20060217349-A1 | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain | OPRL1, OPRK1, OPRD1 | KDM4E 1642/4885FABP4 3119/4885FABP3 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.