⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847645 | 0.86 | TP53 (0.30) | — | |
| SCHEMBL1782031 | 0.75 | — | — | |
| SCHEMBL2051254 | 0.75 | TP53 (0.35) | — | |
| SCHEMBL2051255 | 0.75 | TP53 (0.35) | — | |
| SCHEMBL1782033 | 0.75 | — | — | |
| SCHEMBL16673754 | 0.75 | TP53 (0.35) | — | |
| SCHEMBL7109977 | 0.73 | — | — | |
| SCHEMBL12122482 | 0.73 | — | — | |
| SCHEMBL13742840 | 0.73 | LMNA (0.32) | — | |
| SCHEMBL13567337 | 0.73 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367065-B2 | Targeted polymeric prodrugs containing multifunctional linkers | ENZON PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8110559-B2 | Hindered ester-based biodegradable linkers for oligonucleotide delivery | ENZON PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100279408-A1 | POLYMERIC SHORT INTERFERING RNA CONJUGATES | ENZON PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100234444-A1 | HINDERED ESTER-BASED BIODEGRADABLE LINKERS FOR OLIGONUCLEOTIDE DELIVERY | ENZON PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20090202573-A1 | POLYMERIC CONJUGATES CONTAINING POSITIVELY-CHARGED MOIETIES | ENZON PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |