Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178503 | 0.87 | LMNA (0.53) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL10141265 | 0.85 | ALDH1A1 (0.60) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL4240625 | 0.84 | ALDH1A1 (0.63) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL8192405 | 0.84 | ALDH1A1 (0.59) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL13486446 | 0.81 | KDM4E (0.54) | ALDH1A1ALOX15KDM4EMAPTCYP1A2 | |
| SCHEMBL21676250 | 0.81 | CYP1A2 (0.51) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL20055055 | 0.80 | S1PR4 (0.63) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL9296252 | 0.79 | NT5E (0.60) | ALDH1A1KDM4ELMNAHSD17B10MAPT | |
| SCHEMBL19132613 | 0.79 | KDM4E (0.48) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 | |
| SCHEMBL25497958 | 0.79 | HSD17B10 (0.51) | ALDH1A1ALOX15KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | ALDH1A1 1430/4885ALOX15 3382/4885KDM4E 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.