Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.53 |
| ▸ | MMP13 | P45452 | 13/20 | 0.52 |
| ▸ | MMP2 | P08253 | 12/20 | 0.52 |
| ▸ | MMP3 | P08254 | 12/20 | 0.52 |
| ▸ | MMP1 | P03956 | 12/20 | 0.52 |
| ▸ | MMP7 | P09237 | 11/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159724 | 0.92 | CYP2C9 (0.50) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL1659451 | 0.84 | MMP2 (0.54) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL8283901 | 0.82 | MMP2 (0.76) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL690201 | 0.81 | MMP2 (0.68) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL690202 | 0.81 | MMP2 (0.68) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL6723663 | 0.81 | MMP9 (0.72) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL6723666 | 0.81 | MMP9 (0.72) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL8283226 | 0.81 | MMP2 (0.68) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL7347163 | 0.81 | MMP9 (0.72) | MMP9MMP13MMP2MMP3MMP1 | |
| SCHEMBL5899567 | 0.81 | MMP9 (0.61) | MMP9MMP13MMP2MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825146-B2 | Sulfonamide derivative having isoxazole ring | SHIONOGI & CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-7825146-B2 | Sulfonamide derivative having isoxazole ring | SHIONOGI & CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |