Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13040047 | 0.91 | LMNA (0.49) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL13077497 | 0.88 | ADRB2 (0.58) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL13040052 | 0.82 | ADRB2 (0.56) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL13040046 | 0.80 | ADRB2 (0.60) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL13077480 | 0.79 | ADRB2 (0.51) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL13040043 | 0.75 | NR2E1 (0.44) | ADRB2ADRB1LMNASLC22A1KDM4E | |
| SCHEMBL13077702 | 0.74 | ADRB2 (0.61) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL10833323 | 0.74 | ADRB2 (0.77) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| SCHEMBL10832901 | 0.74 | ADRB2 (0.77) | ADRB2ADRB1LMNASLC22A1HIF1A | |
| Acebutolol SCHEMBL9062035 | 0.73 | ADRB2 (0.98) | ADRB2ADRB1LMNASLC22A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825263-B2 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive | NICOX S.A. (FR) | 2010-11-02 | — | — | US | disclosed |
| US-20070072854-A1 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive | NICOX S.A. (FR) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072854-A1 | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive | ADRB2, ADRB1, ADRA2B | ADRB2 1/4885ADRB1 2/4885LMNA 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.