Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041644 | 0.93 | OPRL1 (0.42) | BRD4OPRM1OPRL1DPP4OPRK1 | |
| SCHEMBL13041639 | 0.81 | PARP1 (0.43) | OPRM1OPRL1DPP4ALDH1A1LMNA | |
| SCHEMBL13041630 | 0.80 | ALDH1A1 (0.43) | OPRM1OPRL1DPP4ALDH1A1LMNA | |
| SCHEMBL13041631 | 0.79 | ENPP2 (0.51) | BRD4OPRM1OPRL1L3MBTL1PARP1 | |
| SCHEMBL13041625 | 0.79 | ALDH1A1 (0.39) | OPRM1OPRL1DPP4ALDH1A1PARP1 | |
| SCHEMBL13041635 | 0.77 | PARP1 (0.43) | ALDH1A1PARP1SMN1; SMN2 | |
| SCHEMBL13041643 | 0.77 | ALOX15 (0.36) | OPRM1OPRL1DPP4ALDH1A1BRS3 | |
| SCHEMBL13041634 | 0.77 | PARP1 (0.43) | ALDH1A1L3MBTL1PARP1BRS3 | |
| SCHEMBL13041624 | 0.75 | C5AR1 (0.47) | OPRM1OPRL1ALDH1A1PARP1OPRK1 | |
| SCHEMBL13015326 | 0.74 | BRD4 (0.42) | BRD4OPRM1OPRL1DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100278835-A1 | NOVEL COMPOUNDS 660 | ASTRAZENECA UK LIMITED (GB) | 2010-11-04 | — | — | US | disclosed |
| US-20100278835-A1 | NOVEL COMPOUNDS 660 | ASTRAZENECA UK LIMITED (GB) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278835-A1 | NOVEL COMPOUNDS 660 | RB1, RPP30, SARS1 | BRD4 2766/4885OPRM1 1102/4885OPRL1 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.