Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GNPAT | O15228 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 6/20 | 0.33 |
| ▸ | CASP2 | P42575 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12773687 | 0.90 | ALDH1A1 (0.40) | ALDH1A1GNPATCASP3CASP2SMN1; SMN2 | |
| SCHEMBL13043586 | 0.85 | LMNA (0.35) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL13043588 | 0.81 | SMN1; SMN2 (0.34) | SMN1; SMN2TSHR | |
| SCHEMBL468693 | 0.77 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL468692 | 0.77 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL10442410 | 0.77 | ALDH1A1 (0.42) | ALDH1A1GNPATSMN1; SMN2KDM4EMAPT | |
| SCHEMBL12774903 | 0.75 | ALDH1A1 (0.38) | ALDH1A1GNPATSMN1; SMN2KDM4EMAPT | |
| SCHEMBL20614482 | 0.75 | CPA1 (0.43) | ALDH1A1GNPATSMN1; SMN2KDM4EMAPT | |
| SCHEMBL13043728 | 0.71 | MAPT (0.44) | SMN1; SMN2MAPTTSHR | |
| SCHEMBL5808284 | 0.71 | TSHR (0.41) | ALDH1A1TSHRTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | VIP, OPRL1, OPRK1 | ALDH1A1 1313/4885GNPAT 618/4885CASP3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.