Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | FURIN | P09958 | 2/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | CPA2 | P48052 | 1/20 | 0.31 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PCSK6 | P29122 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12774903 | 0.90 | ALDH1A1 (0.38) | LMNAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL13043585 | 0.85 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ATRPV1SMN1; SMN2 | |
| SCHEMBL20614482 | 0.82 | CPA1 (0.43) | ALDH1A1SMN1; SMN2CPA1CPA2CPA4 | |
| SCHEMBL468880 | 0.79 | L3MBTL1 (0.42) | LMNAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL468879 | 0.79 | L3MBTL1 (0.42) | LMNAALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL10442581 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL12773687 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MAPTCTSDBACE1 | |
| SCHEMBL13043728 | 0.75 | MAPT (0.44) | LMNASMN1; SMN2MAPT | |
| SCHEMBL13043654 | 0.73 | PLA2G2A (0.42) | LMNASMN1; SMN2MAPT | |
| SCHEMBL13043588 | 0.73 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | VIP, OPRL1, OPRK1 | LMNA 4259/4885ALDH1A1 1313/4885MEN1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.