Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13047404 | 0.89 | GRM2 (0.45) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL15290185 | 0.86 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL13047048 | 0.84 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL13047124 | 0.84 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL13046660 | 0.83 | PDE4D (0.50) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL13047462 | 0.83 | MEN1 (0.47) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL1591117 | 0.82 | GRM2 (0.44) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 | |
| SCHEMBL13047447 | 0.80 | POLB (0.45) | ALDH1A1SMN1; SMN2LMNAKDM4EKMT2A | |
| SCHEMBL13047071 | 0.80 | POLB (0.61) | ALDH1A1KDM4EHPGDGRM2 | |
| SCHEMBL1590792 | 0.79 | SHMT2 (0.49) | ALDH1A1SMN1; SMN2LMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546579-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8546579-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20100292235-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | SECOND GENOME, INC. | 2010-11-18 | — | — | US | disclosed |
| US-20100292235-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | SECOND GENOME, INC. | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292235-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | ALDH1A1 3640/4885SMN1; SMN2 4369/4885LMNA 1911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.