SCHEMBL1304789

SCHEMBL1304789

Cc1c(Cl)cc(C(C)C(N)=O)c(O)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CXCL8 P10145 1/20 0.39
LMNA P02545 1/20 0.36
EPHX1 P07099 2/20 0.33
APP P05067 1/20 0.33
TP53 P04637 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
GABRA1 P14867 1/20 0.32
GABRB1 P18505 1/20 0.32
ALDH1A1 P00352 1/20 0.32
SIRT1 Q96EB6 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4355965 0.72 NNMT (0.38) LMNAALDH1A1L3MBTL1
SCHEMBL31387736 0.70 CXCL8 (0.39) CXCL8EPHX1APP
SCHEMBL16150316 0.69 HSD17B10 (0.50) CXCL8EPHX1APPCYP2C9CYP2C19
SCHEMBL15698348 0.67 LMNA (0.52) LMNATP53CYP2C9CYP2C19SMN1; SMN2
SCHEMBL10771021 0.67 HSD17B10 (0.59) LMNATP53CYP2C9CYP2C19SMN1; SMN2
SCHEMBL17513421 0.67 CXCL8 (0.60) CXCL8LMNASMN1; SMN2ALDH1A1
SCHEMBL7820665 0.67 LMNA (0.58) CXCL8LMNAEPHX1APPTP53
SCHEMBL31532309 0.66 CD44 (0.44) LMNATP53CYP2C9CYP2C19SMN1; SMN2
SCHEMBL2527588 0.66 CD44 (0.44) LMNATP53CYP2C9CYP2C19SMN1; SMN2
SCHEMBL1817192 0.66 CXCL8 (0.64) CXCL8LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8052785-B2 Polymer containing image receiver sheet on support FUJIFILM CORPORATION (JP) 2011-11-08 US disclosed
US-20080242542-A1 INDANILINE DYE, THERMAL TRANSFER RECORDING INK SHEET, THERMAL TRANSFER RECORDING METHOD, COLOR TONER, INKJET INK, AND COLOR FILTER FUJIFILM CORPORATION (JP) 2008-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080242542-A1 INDANILINE DYE, THERMAL TRANSFER RECORDING INK SHEET, THERMAL TRANSFER RECORDING METHOD, COLOR TONER, INKJET INK, AND COLOR FILTER INMT, TYR, IK CXCL8 3980/4885LMNA 3650/4885EPHX1 4219/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.