Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.55 |
| ▸ | NQO2 | P16083 | 7/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410298 | 1.00 | MTNR1A (0.56) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL1470331 | 0.93 | MTNR1A (0.60) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL13235105 | 0.90 | PPARD (0.52) | — | |
| SCHEMBL12214572 | 0.90 | PPARD (0.52) | — | |
| SCHEMBL2466512 | 0.90 | PPARD (0.52) | — | |
| SCHEMBL10394229 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL8884747 | 0.85 | MTNR1A (0.61) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL7566057 | 0.84 | CYP11B1 (0.48) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL9746612 | 0.84 | CYP11B1 (0.44) | MTNR1AMTNR1BNQO2 | |
| Hydrochloric Acid SCHEMBL7302239 | 0.83 | CYP11B1 (0.43) | MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450522-B2 | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders | AMGEN INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450522-B2 | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders | AMGEN INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | AMGEN INC. | 2010-11-25 | — | — | US | disclosed |
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | AMGEN INC. | 2010-11-25 | — | — | US | disclosed |
| WO-2009111056-A1 | CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | AMGEN INC. (US) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | PC, GOT2, CS | MTNR1A 673/4885MTNR1B 654/4885NQO2 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.