Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13050487 | 0.76 | NOTUM (0.46) | ALDH1A1RAB9ALMNAMAPTGAA | |
| SCHEMBL13654945 | 0.74 | NPC1 (0.42) | ALDH1A1RAB9ALMNAMAPTHTT | |
| SCHEMBL19358313 | 0.74 | NPC1 (0.42) | ALDH1A1RAB9ALMNAMAPTHTT | |
| SCHEMBL19358314 | 0.74 | NPC1 (0.42) | ALDH1A1RAB9ALMNAMAPTHTT | |
| SCHEMBL9969978 | 0.72 | ALDH1A1 (0.44) | ALDH1A1RAB9AMAPTHTTNPSR1 | |
| SCHEMBL16954239 | 0.72 | GABRA1 (0.43) | CLCN2ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL20076629 | 0.72 | CLCN2 (0.41) | CLCN2ALDH1A1ABCB1RAB9ALMNA | |
| SCHEMBL9969954 | 0.72 | SIGMAR1 (0.43) | ALDH1A1RAB9ALMNAMAPTHTT | |
| SCHEMBL17225195 | 0.71 | NPC1 (0.40) | ALDH1A1RAB9ALMNAMAPTHTT | |
| SCHEMBL13528941 | 0.70 | DHODH (0.40) | ALDH1A1RAB9ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142426-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF | SIENA BIOTECH S.P.A. (IT) | 2010-12-16 | — | — | WO | disclosed |