Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.38 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17886517 | 0.94 | USP2 (0.41) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL15112835 | 0.92 | CYP3A4 (0.41) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL24363770 | 0.90 | USP2 (0.49) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL13697423 | 0.90 | CYP3A4 (0.34) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL19104238 | 0.88 | USP2 (0.42) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL16624956 | 0.88 | GRIN2D (0.34) | USP2GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL25738932 | 0.84 | USP2 (0.35) | USP2CYP1A2CYP3A4TSHRCYP2D6 | |
| SCHEMBL17281976 | 0.84 | GRIN2D (0.34) | USP2GRIN2DGRIN3BCHRM2CHRM1 | |
| SCHEMBL16117658 | 0.83 | GRIN2D (0.39) | GRIN2DGRIN3BCHRM2CHRM1OPRM1 | |
| SCHEMBL24363769 | 0.82 | USP2 (0.38) | USP2CYP1A2CYP3A4TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2024-02-29 | — | — | US | disclosed |
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2020-02-11 | — | — | US | disclosed |
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
| US-9527876-B2 | Prodrugs of bicyclic substituted pyrimidine type PDE-5 inhibitors | Xuanzhu Pharma Co., Ltd. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-9359371-B2 | Bicyclic substituted pyrimidine compounds | Xuanzhu Pharma Co., Ltd. (CN) | 2016-06-07 | — | — | US | disclosed |
| US-20160046654-A1 | Prodrugs Of Bicyclic Substituted Pyrimidine Type PDE-5 Inhibitors | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2016-02-18 | — | — | US | disclosed |
| US-20150232474-A1 | Bicyclic Substituted Pyrimidine Compounds | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2015-08-20 | — | — | US | disclosed |
| US-8980904-B2 | Heterocyclic substituted pyrimidine compound | Xuanzhu Pharma Co., Ltd. (CN) | 2015-03-17 | — | — | US | disclosed |
| US-20140288063-A1 | Heterocyclic Substituted Pyrimidine Compound | Xuanzhu Pharma Co., Ltd. (CN) | 2014-09-25 | — | — | US | disclosed |
| US-8399465-B2 | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV (BE) | 2013-03-19 | — | — | US | disclosed |
| US-20100292208-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | USP2 3575/4885CYP1A2 3812/4885CYP3A4 3158/4885 |
| US-20100292208-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | LTA4H, LTC4S, LTB4R | USP2 2233/4885CYP1A2 680/4885CYP3A4 140/4885 |
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | USP2 3575/4885CYP1A2 3812/4885CYP3A4 3158/4885 |
| US-20150232474-A1 | Bicyclic Substituted Pyrimidine Compounds | DPYD, UMPS, TYMP | USP2 4361/4885CYP1A2 516/4885CYP3A4 341/4885 |
| US-20140288063-A1 | Heterocyclic Substituted Pyrimidine Compound | PDE3B, PDE5A, PDE3A | USP2 4154/4885CYP1A2 1019/4885CYP3A4 1076/4885 |
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | USP2 3575/4885CYP1A2 3812/4885CYP3A4 3158/4885 |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | USP2 3575/4885CYP1A2 3812/4885CYP3A4 3158/4885 |
| US-20160046654-A1 | Prodrugs Of Bicyclic Substituted Pyrimidine Type PDE-5 Inhibitors | PDE5A, PDE3A, PDE7A | USP2 2245/4885CYP1A2 265/4885CYP3A4 232/4885 |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | USP2 3575/4885CYP1A2 3812/4885CYP3A4 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.