Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.48 |
| ▸ | MMP3 | P08254 | 17/20 | 0.45 |
| ▸ | MMP1 | P03956 | 16/20 | 0.45 |
| ▸ | MMP2 | P08253 | 14/20 | 0.45 |
| ▸ | MMP9 | P14780 | 9/20 | 0.45 |
| ▸ | MMP8 | P22894 | 4/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.45 |
| ▸ | MMP7 | P09237 | 4/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | MMP20 | O60882 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP15 | P51511 | 1/20 | 0.44 |
| ▸ | MMP16 | P51512 | 1/20 | 0.44 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.44 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176007 | 0.84 | CA1 (0.47) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL1176010 | 0.84 | CA1 (0.47) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL4293013 | 0.84 | CA1 (0.47) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL9972547 | 0.82 | MMP1 (0.47) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL6098 | 0.82 | HIF1A (0.34) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL1706304 | 0.82 | HIF1A (0.34) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL8234485 | 0.81 | MMP3 (0.47) | ADAM17MMP3MMP1MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL2286815 | 0.80 | HIF1A (0.33) | ADAM17MMP3MMP1MMP2MMP9 | |
| SCHEMBL192054 | 0.78 | CA2 (0.40) | ADAM17 | |
| SCHEMBL3265337 | 0.78 | ALDH1A1 (0.33) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018032468-A1 | HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2018-02-22 | — | — | WO | disclosed |
| WO-2010144869-A2 | PROTEASE INHIBITORS | NEKTAR THERAPEUTICS (US) | 2010-12-16 | — | — | WO | disclosed |