SCHEMBL1305259

SCHEMBL1305259

C=CC[Si](O)(CC=C)c1ccc(C#Cc2ccc(-c3ccc(C#Cc4ccc([Si](O)(CC=C)CC=C)cc4)cn3)nc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.33
GRM5 P41594 4/20 0.32
MCHR1 Q99705 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1306247 0.76 ACACB (0.32) GRM5MCHR1
SCHEMBL1306337 0.74 HDAC8 (0.34)
SCHEMBL4267425 0.68 NR1H2 (0.35)
SCHEMBL15302725 0.67 ALDH1A1 (0.34)
SCHEMBL4386642 0.65 NR1H2 (0.47)
SCHEMBL4388086 0.62 NR1H2 (0.41)
SCHEMBL14571166 0.61 MAPT (0.42) GRM5
SCHEMBL12112105 0.60 ACACB (0.33)
SCHEMBL4283966 0.60 SMN1; SMN2 (0.44)
SCHEMBL1305334 0.60 ACACB (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8053588-B2 organosilane compounds used as raw materials for synthesis of organosilicon polymer thin films, having a refractive-index controlling function, a light absorbing function, a light emitting function, and a charge transferring function KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2011-11-08 US disclosed
US-8053588-B2 organosilane compounds used as raw materials for synthesis of organosilicon polymer thin films, having a refractive-index controlling function, a light absorbing function, a light emitting function, and a charge transferring function KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2011-11-08 US disclosed
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 US disclosed
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227939-A1 Organosilane compound and organosilica obtained therefrom CARM1, PRMT1, PRMT8 FFAR1 1390/4885GRM5 503/4885MCHR1 533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.