Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306574 | 0.93 | TDP1 (0.46) | MAPTFAAHDRD2CNR1DRD3 | |
| SCHEMBL1305638 | 0.92 | MAPT (0.51) | MAPTLMNAPOLBKMT2ATSHR | |
| SCHEMBL1305640 | 0.92 | MAPT (0.51) | MAPTLMNAPOLBKMT2ATSHR | |
| SCHEMBL1305681 | 0.90 | MAPT (0.49) | MAPTLMNAPOLBKMT2ATSHR | |
| SCHEMBL1305680 | 0.90 | MAPT (0.49) | MAPTLMNAPOLBKMT2ATSHR | |
| SCHEMBL1305479 | 0.86 | MAPT (0.47) | MAPTLMNAPOLBKMT2ATSHR | |
| SCHEMBL1306488 | 0.84 | L3MBTL1 (0.48) | MAPTLMNAKMT2ATSHRALDH1A1 | |
| SCHEMBL2891106 | 0.84 | TDP1 (0.47) | MAPTPOLBKMT2AMEN1FAAH | |
| SCHEMBL2891102 | 0.84 | TDP1 (0.47) | MAPTPOLBKMT2AMEN1FAAH | |
| SCHEMBL1306651 | 0.83 | SCN1A (0.43) | MAPTLMNATSHRALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |