Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 8/20 | 0.45 |
| ▸ | FAAH | O00519 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305476 | 0.93 | MAPT (0.49) | TDP1DRD3FAAHDRD2CNR1 | |
| SCHEMBL2891106 | 0.91 | TDP1 (0.47) | TDP1KDM4EHSD17B10DRD3FAAH | |
| SCHEMBL2891102 | 0.91 | TDP1 (0.47) | TDP1KDM4EHSD17B10DRD3FAAH | |
| SCHEMBL1306651 | 0.88 | SCN1A (0.43) | KDM4EHSD17B10MAPT | |
| SCHEMBL1306488 | 0.88 | L3MBTL1 (0.48) | KDM4EHSD17B10MAPT | |
| SCHEMBL1306577 | 0.85 | DRD3 (0.46) | TDP1KDM4EHSD17B10DRD3FAAH | |
| SCHEMBL1305638 | 0.84 | MAPT (0.51) | KDM4ECNR1MAPTHTT | |
| SCHEMBL1305640 | 0.84 | MAPT (0.51) | KDM4ECNR1MAPTHTT | |
| SCHEMBL1306801 | 0.84 | KDM4E (0.47) | TDP1KDM4EMAPT | |
| SCHEMBL1307053 | 0.84 | L3MBTL1 (0.52) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |