Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306577 | 0.93 | DRD3 (0.46) | CNR1FAAHDRD2DRD3 | |
| SCHEMBL1305638 | 0.89 | MAPT (0.51) | MAPTTSHRLMNAALBMCL1 | |
| SCHEMBL1305640 | 0.89 | MAPT (0.51) | MAPTTSHRLMNAALBMCL1 | |
| SCHEMBL1305476 | 0.86 | MAPT (0.49) | MAPTTSHRLMNACNR1FAAH | |
| SCHEMBL1306490 | 0.85 | KDM4E (0.47) | TSHRLMNASMN1; SMN2KMT2A | |
| SCHEMBL1305681 | 0.84 | MAPT (0.49) | MAPTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL1305680 | 0.84 | MAPT (0.49) | MAPTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL1306652 | 0.84 | LMNA (0.43) | MAPTTSHRLMNACNR1FAAH | |
| SCHEMBL1307055 | 0.83 | ALDH1A1 (0.47) | MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL1306803 | 0.82 | HPGD (0.43) | MAPTTSHRLMNAMCL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |