Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.46 |
| ▸ | FAAH | O00519 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305479 | 0.93 | MAPT (0.47) | DRD3FAAHDRD2CNR1 | |
| SCHEMBL1306652 | 0.89 | LMNA (0.43) | DRD3FAAHDRD2CNR1KDM4E | |
| SCHEMBL1306490 | 0.89 | KDM4E (0.47) | KDM4EHSD17B10 | |
| SCHEMBL2891102 | 0.88 | TDP1 (0.47) | DRD3FAAHDRD2CNR1TDP1 | |
| SCHEMBL2891106 | 0.88 | TDP1 (0.47) | DRD3FAAHDRD2CNR1TDP1 | |
| SCHEMBL1306574 | 0.85 | TDP1 (0.46) | DRD3FAAHDRD2CNR1TDP1 | |
| SCHEMBL1307055 | 0.85 | ALDH1A1 (0.47) | KDM4E | |
| SCHEMBL1306803 | 0.84 | HPGD (0.43) | TDP1KDM4ETRPM4 | |
| SCHEMBL1305638 | 0.81 | MAPT (0.51) | CNR1KDM4E | |
| SCHEMBL1307208 | 0.81 | TRPM4 (0.41) | TDP1KDM4ETRPM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |