Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196940 | 0.81 | — | — | |
| SCHEMBL12927729 | 0.81 | NPC1 (0.32) | KDM4ENPC1KMT2AMEN1 | |
| SCHEMBL12646947 | 0.77 | KDM4E (0.48) | KDM4EP2RX7DYRK1ACLK4NPC1 | |
| SCHEMBL14236101 | 0.77 | SLC40A1 (0.31) | DYRK1A | |
| SCHEMBL12927740 | 0.76 | CSF1R (0.40) | — | |
| SCHEMBL13976937 | 0.75 | KDM4E (0.41) | KDM4EDYRK1ACLK4GPR39 | |
| SCHEMBL12960537 | 0.75 | P2RX7 (0.41) | KDM4EP2RX7KMT2A | |
| SCHEMBL13056389 | 0.73 | CYP3A4 (0.45) | KDM4EDYRK1ACLK4GPR39 | |
| SCHEMBL14194151 | 0.73 | CYP3A4 (0.32) | KMT2AMEN1TGFBR1 | |
| SCHEMBL12927324 | 0.71 | GAA (0.35) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846941-B2 | Compounds modulating c-kit and c-fms activity and uses therefor | PLEXXIKON, INC. (US) | 2010-12-07 | — | — | US | disclosed |