Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306323 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1306318 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1306938 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1305962 | 0.86 | L3MBTL1 (0.48) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1305961 | 0.86 | L3MBTL1 (0.48) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1305790 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL29525119 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1305792 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10L3MBTL1NPC1 | |
| SCHEMBL1306562 | 0.81 | HPGD (0.44) | KDM4EALDH1A1CYP1A2HPGDTSHR | |
| SCHEMBL1306264 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1L3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |