Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13868184 | 0.92 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL5568688 | 0.83 | MEN1 (0.35) | MEN1KMT2AEPHX2 | |
| SCHEMBL6348493 | 0.78 | MEN1 (0.34) | MEN1KMT2AEPHX2 | |
| SCHEMBL5563190 | 0.77 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL5697624 | 0.77 | EPHX2 (0.39) | MEN1KMT2AEPHX2 | |
| SCHEMBL5567918 | 0.77 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL5562876 | 0.77 | MEN1 (0.35) | MEN1KMT2AEPHX2 | |
| SCHEMBL6354331 | 0.77 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL5568128 | 0.75 | MAPK1 (0.39) | MEN1KMT2AEPHX2 | |
| SCHEMBL5011348 | 0.74 | MEN1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719757-B1 | BICYCLO DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2013-10-09 | — | — | EP | disclosed |
| EP-1712547-B1 | BICYCLOESTER DERIVATIVE | KYORIN SEIYAKU KK (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-8053465-B2 | Bicycloester derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-7754757-B2 | Bicycloester derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |
| US-20100093825-A1 | Bicycloester derivative | FUKUDA YASUMICHI | 2010-04-15 | — | — | US | disclosed |
| US-7560569-B2 | (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile, for treating type II diabetes; increase glucagon-like peptide activity | KYORIN PHARMACEUTICAL CO., LTD (JP) | 2009-07-14 | — | — | US | disclosed |
| US-7514571-B2 | Bicyclo derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2009-04-07 | — | — | US | disclosed |
| US-20080146818-A1 | Dipeptidylpeptidase IV (DPP-IV) inhibitory activity; (2S,4S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)); diabetes | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-06-19 | — | — | US | disclosed |
| US-20070265320-A1 | Bicycloamide Derivative | KYORIN PHARMACEUTICAL CO., LTD (JP) | 2007-11-15 | — | — | US | disclosed |
| US-20070167501-A1 | Bicyclo derivative | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1719757-A1 | BICYCLO DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |
| EP-1717225-A1 | BICYCLIC AMIDE DERIVATIVES | Kyorin Pharmaceutical Co., Ltd. (JP) | 2006-11-02 | — | — | EP | disclosed |
| EP-1712547-A1 | BICYCLOESTER DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2006-10-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265320-A1 | Bicycloamide Derivative | DPP4, DPP7, DPP9 | MEN1 3700/4885KMT2A 1596/4885EPHX2 4555/4885 |
| US-20100093825-A1 | Bicycloester derivative | DPP4, DPP7, DPP3 | MEN1 4161/4885KMT2A 3406/4885EPHX2 3785/4885 |
| US-20070167501-A1 | Bicyclo derivative | DPP4, DPP7, DPP9 | MEN1 3623/4885KMT2A 1721/4885EPHX2 4784/4885 |
| US-20080146818-A1 | Dipeptidylpeptidase IV (DPP-IV) inhibitory activity; (2S,4S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)); diabetes | DPP4, DPP7, DPP3 | MEN1 3917/4885KMT2A 3348/4885EPHX2 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.