Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060677 | 1.00 | DRD2 (0.60) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL13005448 | 0.90 | HTR1A (0.53) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL13005433 | 0.90 | HTR1A (0.53) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL17790224 | 0.84 | ROCK2 (0.61) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL18901194 | 0.83 | ROCK2 (0.60) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL4572920 | 0.82 | DRD2 (0.60) | DRD2HTR1AABCG2HSD17B10KMT2A | |
| SCHEMBL19954197 | 0.82 | ROCK2 (0.59) | DRD2HTR1AROCK2ROCK1ABCG2 | |
| SCHEMBL11919266 | 0.82 | DRD2 (0.67) | DRD2ABCG2HSD17B10 | |
| SCHEMBL4341169 | 0.81 | MCHR1 (0.69) | DRD2ABCG2HSD17B10KMT2A | |
| SCHEMBL13060816 | 0.81 | ABCG2 (0.62) | DRD2ABCG2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |