Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060857 | 0.96 | FYN (0.52) | FYNSIGMAR1TMEM97SMN1; SMN2METAP2 | |
| SCHEMBL13060639 | 0.92 | FYN (0.55) | FYNSIGMAR1TMEM97SMN1; SMN2MEN1 | |
| SCHEMBL12055875 | 0.92 | SIGMAR1 (0.59) | FYNSIGMAR1TMEM97SMN1; SMN2HPGD | |
| SCHEMBL13060861 | 0.91 | BCL2 (0.56) | FYNSIGMAR1TMEM97SMN1; SMN2HPGD | |
| SCHEMBL173049 | 0.89 | CFD (0.62) | FYNSIGMAR1TMEM97SMN1; SMN2METAP2 | |
| SCHEMBL13005460 | 0.87 | FYN (0.53) | FYNSIGMAR1TMEM97SMN1; SMN2METAP2 | |
| SCHEMBL24061105 | 0.85 | FYN (0.57) | FYNSMN1; SMN2METAP2HPGDMEN1 | |
| SCHEMBL12333454 | 0.84 | USP2 (0.55) | FYNSIGMAR1TMEM97SMN1; SMN2MEN1 | |
| SCHEMBL24061104 | 0.84 | FYN (0.59) | FYNSMN1; SMN2METAP2HPGDMEN1 | |
| SCHEMBL13005464 | 0.83 | FYN (0.49) | FYNSIGMAR1TMEM97SMN1; SMN2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |