Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 3/20 | 0.62 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060801 | 0.89 | FYN (0.55) | FYNSIGMAR1TMEM97CHUKINSR | |
| SCHEMBL13005460 | 0.86 | FYN (0.53) | FYNSIGMAR1TMEM97CHUKINSR | |
| SCHEMBL13060857 | 0.85 | FYN (0.52) | FYNSIGMAR1TMEM97HPGDMEN1 | |
| SCHEMBL172995 | 0.85 | CFD (0.56) | CFDSIGMAR1TMEM97ALDH1A1F11 | |
| SCHEMBL5109753 | 0.84 | LOXL2 (0.54) | CFDFYNSIGMAR1TMEM97MEN1 | |
| SCHEMBL24061105 | 0.84 | FYN (0.57) | FYNCHUKINSRMAPK8CAMKK2 | |
| SCHEMBL24061104 | 0.82 | FYN (0.59) | FYNCHUKINSRMAPK8CAMKK2 | |
| SCHEMBL13005464 | 0.82 | FYN (0.49) | FYNSIGMAR1TMEM97HPGDMEN1 | |
| SCHEMBL13060639 | 0.81 | FYN (0.55) | CFDFYNSIGMAR1TMEM97MEN1 | |
| SCHEMBL12055875 | 0.81 | SIGMAR1 (0.59) | FYNSIGMAR1TMEM97HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |