Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13108707 | 0.92 | MAPT (0.85) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29556760 | 0.90 | ALDH1A1 (0.81) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2849974 | 0.90 | ALDH1A1 (0.81) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL32668864 | 0.90 | ALDH1A1 (0.81) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13108734 | 0.88 | ALDH1A1 (0.79) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3445210 | 0.88 | SMN1; SMN2 (0.81) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15305956 | 0.82 | MEN1 (0.80) | MAPTSMN1; SMN2KMT2AMEN1NTSR1 | |
| SCHEMBL24715264 | 0.81 | MAPT (0.69) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11772051 | 0.81 | ALDH1A1 (0.69) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20387001 | 0.81 | ALDH1A1 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053573-B2 | Monomer 5, 6-diphenyl-1.2.4-traizinic derivatives and the use thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2011-11-08 | — | — | US | disclosed |
| US-8053573-B2 | Monomer 5, 6-diphenyl-1.2.4-traizinic derivatives and the use thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2011-11-08 | — | — | US | disclosed |
| US-8053573-B2 | Monomer 5, 6-diphenyl-1.2.4-traizinic derivatives and the use thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2011-11-08 | — | — | US | disclosed |
| EP-1751122-B1 | MONOMER 5,6-DIPHENYL-1,2,4-TRIAZINIC DERIVATIVES AND THE USE THEREOF | FABRE PIERRE DERMO COSMETIQUE (FR) | 2010-03-17 | — | — | EP | disclosed |
| US-20080299055-A1 | Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2008-12-04 | — | — | US | disclosed |
| US-20080299055-A1 | Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2008-12-04 | — | — | US | disclosed |
| US-20080299055-A1 | Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080299055-A1 | Monomer 5, 6-Diphenyl-1.2.4-Traizinic Derivatives and the Use Thereof | POT1, TELO2, CLIC1 | MAPT 4453/4885ALDH1A1 581/4885SMN1; SMN2 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.