Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 6/20 | 0.55 |
| ▸ | XDH | P47989 | 1/20 | 0.55 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.55 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.53 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.53 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.53 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.53 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.53 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.53 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.53 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29951632 | 1.00 | PTPN1 (0.56) | PTPN1MEN1KMT2APOLBALOX15 | |
| SCHEMBL29954142 | 0.84 | PTPN1 (0.54) | PTPN1MEN1KMT2APOLBALOX15 | |
| SCHEMBL21591443 | 0.73 | PTPN1 (0.56) | PTPN1MEN1KMT2APOLBMAOA | |
| SCHEMBL10994834 | 0.73 | ALOX15 (0.59) | MEN1KMT2APOLBALOX15ALOX12 | |
| SCHEMBL11151168 | 0.72 | ALOX15 (0.55) | MEN1KMT2AALOX15ALOX12XDH | |
| SCHEMBL234354 | 0.72 | ALOX15 (0.75) | MEN1KMT2AALOX15ALOX12XDH | |
| SCHEMBL11872015 | 0.72 | PTPN1 (1.00) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL29950744 | 0.72 | PTPN1 (1.00) | PTPN1MEN1KMT2APOLBGAA | |
| SCHEMBL30533224 | 0.71 | XDH (1.00) | MEN1KMT2AALOX15ALOX12XDH | |
| SCHEMBL28705298 | 0.71 | ALOX15 (0.73) | MEN1KMT2AALOX15ALOX12XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528758-B | [(4-oxo-4h-chromen-3-yl)-hydroxy methyl]- or [(4-oxo-4h-chromen-3-yl)-methyl]-phosphonic acid derivates | MERCK PATENT GMBH | 2012-06-13 | — | — | CN | disclosed |
| US-8052963-B2 | [(4-oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-08 | — | — | US | disclosed |
| US-8052963-B2 | [(4-oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-08 | — | — | US | disclosed |
| US-8052963-B2 | [(4-oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-08 | — | — | US | disclosed |
| EP-1979337-B1 | CHROMEN-4-ONE DERIVATIVES AS A SELF-TANNING SUBSTANCE | MERCK PATENT GMBH (DE) | 2011-05-25 | — | — | EP | disclosed |
| EP-2134732-B1 | [(4-OXO-4H-CHROMEN-3-YL)-HYDROXY METHYL]- OR [(4-OXO-4H-CHROMEN-3-YL)-METHYL]-PHOSPHONIC ACID DERIVATES | MERCK PATENT GMBH (DE) | 2010-11-24 | — | — | EP | disclosed |
| EP-2134732-B1 | [(4-OXO-4H-CHROMEN-3-YL)-HYDROXY METHYL]- OR [(4-OXO-4H-CHROMEN-3-YL)-METHYL]-PHOSPHONIC ACID DERIVATES | MERCK PATENT GMBH (DE) | 2010-11-24 | — | — | EP | disclosed |
| US-20100004209-A1 | [(4-Oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004209-A1 | [(4-Oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004209-A1 | [(4-Oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-07 | — | — | US | disclosed |
| CN-101528758-A | [(4-oxo-4h-chromen-3-yl)-hydroxy methyl]- or [(4-oxo-4h-chromen-3-yl)-methyl]-phosphonic acid derivates | MERCK PATENT GMBH (DE) | 2009-09-09 | — | — | CN | disclosed |
| US-20090220438-A1 | CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1979337-A1 | CHROMEN-4-ONE DERIVATIVES AS A SELF-TANNING SUBSTANCE | Merck Patent GmbH (DE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008052631-A1 | [(4-OXO-4H-CHROMEN-3-YL)-HYDROXY METHYL]- OR [(4-OXO-4H-CHROMEN-3-YL)-METHYL]-PHOSPHONIC ACID DERIVATES | MERCK PATENT GMBH (DE) | 2008-05-08 | — | — | WO | disclosed |
| WO-2007087956-A1 | CHROMEN-4-ONE DERIVATIVES AS A SELF-TANNING SUBSTANCE | MERCK PATENT GMBH (DE) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220438-A1 | CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE | C9, CYP8B1, TYR | PTPN1 4281/4885MEN1 965/4885KMT2A 2386/4885 |
| US-20100004209-A1 | [(4-Oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives | H1-4, H1-0, H1-5 | PTPN1 720/4885MEN1 318/4885KMT2A 723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.