Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895823 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBGAAHPGD | |
| SCHEMBL2895817 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBGAAHPGD | |
| SCHEMBL1306225 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBGAAHPGD | |
| SCHEMBL1306224 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBGAAHPGD | |
| SCHEMBL1306160 | 0.83 | KMT2A (0.45) | ALDH1A1KDM4EPOLBHPGDTSHR | |
| SCHEMBL1306803 | 0.81 | HPGD (0.43) | ALDH1A1KDM4EPOLBLMNAGAA | |
| SCHEMBL1306245 | 0.80 | HPGD (0.49) | ALDH1A1KDM4EPOLBLMNAGAA | |
| SCHEMBL1305803 | 0.80 | DHODH (0.43) | ALDH1A1KDM4EPOLBGAAHPGD | |
| SCHEMBL1306577 | 0.79 | DRD3 (0.46) | KDM4E | |
| SCHEMBL1305479 | 0.79 | MAPT (0.47) | POLBLMNAMAPTTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |