Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22682041 | 0.95 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CALDH1A1CA12 | |
| SCHEMBL12677318 | 0.83 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CALDH1A1RAB9A | |
| SCHEMBL12677327 | 0.78 | DRD2 (0.43) | ADRA2AADRA2BADRA2CALDH1A1HSD17B10 | |
| SCHEMBL14404571 | 0.77 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CALDH1A1CA12 | |
| SCHEMBL672098 | 0.77 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CALDH1A1CA12 | |
| SCHEMBL30632049 | 0.77 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CALDH1A1CA12 | |
| SCHEMBL14515903 | 0.75 | CYP2A6 (0.50) | ADRA2AADRA2BADRA2CALDH1A1RAB9A | |
| SCHEMBL13114089 | 0.74 | MAPT (0.35) | ADRA2AADRA2BADRA2CALDH1A1RAB9A | |
| SCHEMBL11662508 | 0.74 | MAPT (0.56) | ALDH1A1CA12CA1CA2HSD17B10 | |
| SCHEMBL3783508 | 0.74 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141690-A2 | INDANE ANALOGS AND USE AS PHARMACEUTICAL AGENTS AND PROCESS OF MAKING | DARA BIOSCIENCES, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | ADRA2A 270/4885ADRA2B 200/4885ADRA2C 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.