Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065213 | 0.91 | LMNA (0.57) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13065011 | 0.88 | LMNA (0.55) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13064397 | 0.87 | PKM (0.47) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13064395 | 0.85 | SMN1; SMN2 (0.63) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13065033 | 0.84 | LMNA (0.59) | LMNAKMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL13064516 | 0.84 | LMNA (0.60) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13065202 | 0.83 | CNR2 (0.60) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13065200 | 0.82 | LMNA (0.52) | LMNAKMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL13065010 | 0.82 | HTR2B (0.51) | LMNAKMT2AHPGDMEN1 | |
| SCHEMBL303313 | 0.81 | LMNA (0.57) | LMNAKMT2AHPGDMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130638-A1 | SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EVOTEC AG (DE) | 2010-11-18 | — | — | WO | disclosed |