Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.39 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.39 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.39 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306596 | 0.93 | ADAMTS5 (0.39) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1306111 | 0.92 | PTPN1 (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1306562 | 0.86 | HPGD (0.44) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1307959 | 0.86 | KDM4E (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1307956 | 0.86 | KDM4E (0.46) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1306149 | 0.85 | KMT2A (0.43) | POLBLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL1306816 | 0.85 | LMNA (0.47) | POLBLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL1306595 | 0.84 | CNR2 (0.41) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1308956 | 0.84 | ALDH1A1 (0.40) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1306593 | 0.84 | CNR2 (0.41) | PLAAT3PLAAT5PLAAT2PLAAT4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |