Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305885 | 0.88 | ALDH1A1 (0.49) | LMNAL3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL1306596 | 0.85 | ADAMTS5 (0.39) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1306597 | 0.85 | PLAAT3 (0.39) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1305819 | 0.84 | TDP1 (0.50) | LMNAL3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL28392351 | 0.84 | TDP1 (0.50) | LMNAL3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL1306111 | 0.83 | PTPN1 (0.46) | LMNAALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL1306562 | 0.83 | HPGD (0.44) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1308956 | 0.81 | ALDH1A1 (0.40) | LMNAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1305963 | 0.80 | KDM4E (0.45) | LMNAL3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL1307181 | 0.79 | ALDH1A1 (0.43) | LMNAALDH1A1HPGDKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |