Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.34 |
| ▸ | TRHR | P34981 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071425 | 0.91 | ACE (0.38) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL12831720 | 0.89 | ACE (0.37) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL12831754 | 0.85 | ACE (0.41) | F2ACEF10 | |
| SCHEMBL13071524 | 0.84 | HTR1A (0.36) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13071668 | 0.84 | ACE (0.33) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13071436 | 0.83 | ACE (0.33) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13072094 | 0.83 | USP2 (0.34) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13071914 | 0.82 | F2 (0.33) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13071629 | 0.82 | ALDH1A1 (0.36) | F2PRSS1PRSS2PRSS3ACE | |
| SCHEMBL13071900 | 0.82 | TACR1 (0.36) | F2PRSS1PRSS2PRSS3ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |