Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.33 |
| ▸ | F2R | P25116 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072094 | 0.91 | USP2 (0.34) | TACR1USP2MEN1KMT2ANPSR1 | |
| SCHEMBL13071403 | 0.90 | USP2 (0.34) | TACR1USP2MEN1KMT2ANPSR1 | |
| SCHEMBL13072076 | 0.86 | ACE (0.35) | TACR1USP2MEN1KMT2ANPSR1 | |
| SCHEMBL13071629 | 0.83 | ALDH1A1 (0.36) | NPSR1ACEF2PRSS1PRSS2 | |
| SCHEMBL13071524 | 0.82 | HTR1A (0.36) | KMT2AACEF2PRSS1PRSS2 | |
| SCHEMBL13071897 | 0.82 | F2 (0.41) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL13071425 | 0.82 | ACE (0.38) | ACEF2PRSS1PRSS2PRSS3 | |
| SCHEMBL12831783 | 0.82 | F2R (0.34) | F2RACEF2PRSS1PRSS2 | |
| SCHEMBL13071885 | 0.82 | XIAP (0.35) | MAPTSMN1; SMN2F2 | |
| SCHEMBL13071454 | 0.81 | DPP4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |