Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400850 | 0.93 | HTR2C (0.45) | HTR2CNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL13072014 | 0.92 | HTR2C (0.47) | HTR2CALDH1A1HPGDHRH3 | |
| SCHEMBL13072012 | 0.92 | HTR2C (0.47) | HTR2CALDH1A1HPGDHRH3 | |
| SCHEMBL3402627 | 0.85 | RAB9A (0.50) | HTR2CNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3405361 | 0.85 | RAB9A (0.53) | HTR2CNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3400125 | 0.85 | HTR2C (0.56) | HTR2CNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3401060 | 0.84 | HTR2C (0.48) | HTR2CALDH1A1HPGDHRH3 | |
| SCHEMBL3399981 | 0.84 | HTR2C (0.48) | HTR2CALDH1A1HPGDHRH3 | |
| SCHEMBL14546080 | 0.84 | HTR2C (0.45) | HTR2CALDH1A1HPGDHRH3NPSR1 | |
| SCHEMBL3402441 | 0.83 | NPC1 (0.47) | HTR2CNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | LIGAND PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | HRH3, HRH4, HRH2 | HTR2C 416/4885NPC1 2005/4885RAB9A 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.