Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076689 | 0.89 | NR1H3 (0.45) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2C9 | |
| SCHEMBL1041122 | 0.83 | RAB9A (0.40) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL4020084 | 0.76 | RAB9A (0.44) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL13596187 | 0.74 | NR1H3 (0.49) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2C9 | |
| SCHEMBL12405420 | 0.74 | NR1H3 (0.50) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL3058686 | 0.74 | F2 (0.39) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL14133758 | 0.72 | KDM4C (0.39) | RAB9ASMN1; SMN2NPC1TDP2NR1H3 | |
| SCHEMBL14293751 | 0.72 | NR1H3 (0.34) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL1040692 | 0.72 | NR1H3 (0.47) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2C9 | |
| SCHEMBL1037764 | 0.70 | TDP2 (0.43) | RAB9ASMN1; SMN2NPC1CYP1A2TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132743-A1 | CORTICOSTEROID BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20090318396-A1 | CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | GILEAD SCIENCES, INC. (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318396-A1 | CORTICOSTEROID LINKED BETA-AGONIST COMPOUNDS FOR USE IN THERAPY | ADRB1, ADRB2, ADRB3 | RAB9A 3676/4885SMN1; SMN2 2544/4885NPC1 2658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.