Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307914 | 0.75 | SLC6A3 (0.44) | ALDH1A1LMNAKDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL506978 | 0.75 | SLC6A3 (0.44) | ALDH1A1LMNAKDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL1193499 | 0.75 | SLC6A3 (0.44) | ALDH1A1LMNAKDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL27772497 | 0.75 | ATM (0.40) | ALDH1A1LMNAATMHPGDSKDM4E | |
| SCHEMBL1918767 | 0.74 | SLC6A2 (0.38) | ALDH1A1LMNAATMKDM4ESMN1; SMN2 | |
| SCHEMBL23611650 | 0.74 | ALDH1A1 (0.34) | ALDH1A1HPGDS | |
| SCHEMBL27608304 | 0.73 | LMNA (0.34) | ALDH1A1LMNAATMHPGDSKDM4E | |
| SCHEMBL31675926 | 0.72 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL21193426 | 0.71 | VNN1 (0.37) | ALDH1A1LMNAHPGDSKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28076130 | 0.71 | LMNA (0.33) | ALDH1A1LMNAATMHPGDSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053457-B2 | 3-imidazolyl-indoles for the treatment of proliferative diseases | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | NOVARTIS AG (CH) | 2010-05-20 | — | — | US | disclosed |
| EP-2142535-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis Ag (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | MDM4, TP53, MDM2 | ALDH1A1 2589/4885LMNA 2574/4885ATM 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.