Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306663 | 0.82 | PKM (0.48) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL1027492 | 0.76 | ATAD2 (0.55) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL24982338 | 0.76 | PKM (0.50) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL16361867 | 0.76 | ALDH1A1 (0.41) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL16154946 | 0.75 | PKM (0.47) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL30881275 | 0.72 | ALDH1A1 (0.41) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL1029530 | 0.72 | ATAD2 (0.55) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL25105480 | 0.72 | ALDH1A1 (0.44) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL16362387 | 0.72 | ALDH1A1 (0.41) | PKMKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7504142 | 0.72 | MAPT (0.47) | PKMKMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129596-A1 | PMK2 MODULATORS FOR USE IN THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |