Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CD74 | P04233 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029530 | 0.85 | ATAD2 (0.55) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL30881275 | 0.85 | ALDH1A1 (0.41) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1027492 | 0.85 | ATAD2 (0.55) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL25105480 | 0.85 | ALDH1A1 (0.44) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL16362387 | 0.85 | ALDH1A1 (0.41) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL24982338 | 0.85 | PKM (0.50) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL16361867 | 0.85 | ALDH1A1 (0.41) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1026696 | 0.83 | HTT (0.45) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL13075332 | 0.82 | PKM (0.47) | PKMALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1027908 | 0.81 | HTT (0.50) | PKMALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427441-B1 | PKM2 ACTIVATORS FOR USE IN THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |