Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076725 | 0.92 | GRIN1 (0.50) | EPHX2GRIN1GRIN2B | |
| SCHEMBL3803815 | 0.85 | EPHX2 (0.49) | EPHX2MAPTALDH1A1POLBCNR2 | |
| SCHEMBL13075758 | 0.85 | MAPT (0.45) | EPHX2MAPTALDH1A1POLBCNR1 | |
| SCHEMBL13075759 | 0.84 | MCHR1 (0.44) | CNR1CNR2 | |
| SCHEMBL13076533 | 0.83 | MAPT (0.44) | EPHX2MAPTALDH1A1POLBPPARG | |
| SCHEMBL13075757 | 0.82 | GRIN1 (0.51) | EPHX2GRIN1GRIN2B | |
| SCHEMBL3724166 | 0.80 | ALDH1A1 (0.46) | EPHX2MAPTALDH1A1POLBCNR2 | |
| SCHEMBL3716663 | 0.80 | ALDH1A1 (0.48) | EPHX2MAPTALDH1A1POLBPPARG | |
| SCHEMBL13076485 | 0.78 | GRIN1 (0.50) | EPHX2ALDH1A1CNR2PPARGGRIN1 | |
| SCHEMBL3793849 | 0.77 | MAPT (0.46) | EPHX2MAPTALDH1A1POLBCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |