Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803815 | 0.88 | EPHX2 (0.49) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL3716663 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL3793849 | 0.84 | MAPT (0.46) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL13076533 | 0.83 | MAPT (0.44) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL3719481 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL13075758 | 0.80 | MAPT (0.45) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL13075698 | 0.80 | EPHX2 (0.45) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL13075757 | 0.77 | GRIN1 (0.51) | EPHX2 | |
| SCHEMBL3798181 | 0.75 | EPHX2 (0.49) | ALDH1A1MAPTPOLBEPHX2KMT2A | |
| SCHEMBL13076041 | 0.73 | MAPT (0.45) | ALDH1A1MAPTPOLBEPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | claimed |
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |