Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803815 | 0.90 | EPHX2 (0.49) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL13076533 | 0.85 | MAPT (0.44) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL3724166 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL3793849 | 0.81 | MAPT (0.46) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL3719481 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL13075698 | 0.80 | EPHX2 (0.45) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL13075758 | 0.80 | MAPT (0.45) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL13075757 | 0.78 | GRIN1 (0.51) | EPHX2GRIN1GRIN2B | |
| SCHEMBL3798181 | 0.78 | EPHX2 (0.49) | ALDH1A1MAPTPOLBEPHX2PPARG | |
| SCHEMBL13076041 | 0.76 | MAPT (0.45) | ALDH1A1MAPTPOLBEPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | claimed |